Abstract

Review Article

Natural Rubber Latex on Medical Applications

G Barrera Torres*, JC Rodriguez Urbina, Renivaldo Jose dos Santos, Flavio C Cabrera, Juan C Sánchez G and Jaime A Jaramillo Carvalho

Published: 06 December, 2023 | Volume 4 - Issue 2 | Pages: 089-093

In this review, latex from the Hevea Brasiliensis tree is presented as a material originating from nature, used to produce natural rubber, raw material for countless products for industry, as well as the manufacture of preservatives, and gloves, among others. Nowadays, its potential is expanding into various technological areas, one of which is biomedical, as described in this article. Latex has the possibility of being preserved using ammonium, which is a chemical of high health risk, but nowadays it is being substituted by acid systems excluding traditional chemicals. With these new preservation processes, the prospective use of latex for the design of biosensor scaffolds for drug release, and as membranes that can replace synthetic latex in patches for bioremediation in soft and bone tissues, synthetic muscles, membranes for biological micro laboratories, among others, is being studied to optimize its possibilities.

Read Full Article HTML DOI: 10.29328/journal.jcmhs.1001040 Cite this Article Read Full Article PDF

Keywords:

Natural rubber latex; Biomedical; Synthetic tissues; Membranes; Electrospinning

References

  1. Yamashita S, Takahashi S. Molecular Mechanisms of Natural Rubber Biosynthesis. Annu Rev Biochem. 2020 Jun 20; 89:821-851. doi: 10.1146/annurev-biochem-013118-111107. Epub 2020 Mar 30. PMID: 32228045.
  2. Floriano JF, Emanueli C, Vega S, Barbosa AMP, Oliveira RG, Floriano EAF, Graeff CFO, Abbade JF, Herculano RD, Sobrevia L, Rudge MVC; DIAMATER Study Group. Pro-angiogenic approach for skeletal muscle regeneration. Biochim Biophys Acta Gen Subj. 2022 Feb;1866(2):130059. doi: 10.1016/j.bbagen.2021.130059. Epub 2021 Nov 16. PMID: 34793875.
  3. Gandini A, M Lacerda T. Monomers and Macromolecular Materials from Renewable Resources: State of the Art and Perspectives. Molecules. 2021 Dec 28;27(1):159. doi: 10.3390/molecules27010159. PMID: 35011391; PMCID: PMC8746301.
  4. Corduas F, Dimitrios A. Mancuso LE. Next-generation surgical meshes for drug delivery and tissue engineering applications: materials, design, and emerging manufacturing Technologies. Bio-Design and Manufacturing. 2021; 4:278–310. doi.org/10.1007/s42242-020-00108-1
  5. Andrade KL, Ramlow H, Floriano JF, Acosta ED, Faita FL, Machado RAF. Latex and natural rubber: recent advances for biomedical applications. Polymers: Science and Technology. 2022; 32(2):e2022015. doi.org/10.1590/0104-1428.20210114.
  6. Guerra NB, Sant'Ana Pegorin G, Boratto MH, de Barros NR, de Oliveira Graeff CF, Herculano RD. Biomedical applications of natural rubber latex from the rubber tree Hevea brasiliensis. Mater Sci Eng C Mater Biol Appl. 2021 Jul; 126:112126. doi: 10.1016/j.msec.2021.112126. Epub 2021 Apr 22. PMID: 34082943.
  7. Chaikumpollert O, Yamamoto Y, Suchiva K, Kawahara S. Protein-free natural rubber. Colloid Polym Sci. 2012; 290:331–338. doi 10.1007/s00396-011-2549-y.
  8. Nguyen Thi Ngoc A, Vu Trung N, Khanh Pham D, Phan Minh Q, Than Van H, Nguyen Thi Q, Tran Quang T, Ha Nguyen T, Ngoc Nguyen M, Tran Thi T. Improvement in thermal and mechanical properties of Vietnam deproteinized natural rubber via graft copolym. with styrene/acrylonitrile and diimide transfer hydrogenation. Polymer Bulletin. doi.org/10.1007/s00289-023-04705-9.
  9. Marques L, Martinez G, Guidelli É, Tamashiro J, Segato R, Payão SLM, Baffa O, Kinoshita A. Performance on Bone Regeneration of a Silver Nanoparticle Delivery System Based on Natural Rubber Membrane NRL-AgNP. Springler. Coatings. 10, 323. 2023. doi:10.3390/coatings10040323
  10. Lima AF, Pegorin GS, Miranda MCR, Cachaneski-Lopes JP, Silva WM, Borges FA, Guerra NB, Herculano RD, Batagin-Neto A. Ibuprofen-loaded biocompatible latex membrane for drug release: Characterization and molecular modeling. J Appl Biomater Funct Mater. 2021 Jan-Dec;19:22808000211005383. doi: 10.1177/22808000211005383. PMID: 33781110.
  11. Amnuaypornsri S, Sakdapipanich J, Tanaka Y. Highly purified natural rubber by saponification of latex: analysis of green and cured properties, J. Appl. Polym. Sci. 2010; 118:3524–3531. doi.org/10.1002/app.32699
  12. Boratto MH, Nozella NL, Ramos RA Jr. da Silva RA, Graeff CFO. Flexible conductive blend of natural rubber latex with PEDOT:PSS. APL Mater. 2020; 8:121107. doi.org/10.1063/5.0017936
  13. Gonzalez E, Barquero A, Muñoz-Sanchez B, Paulis M, Leiza JR. Green Electrospinning of Polymer Latexes: A Systematic Study of the Effect of Latex Properties on Fiber Morphology. Nanomaterials (Basel). 2021 Mar 11;11(3):706. doi: 10.3390/nano11030706. PMID: 33799700; PMCID: PMC7999345.
  14. Andrade KL, Ramlow H, Floriano JF, Diz Acosta E, Fabrício LF, Francisco RAM. Latex and natural rubber: processing techniques for biomedical applications. Brazilian J. of Chemical Eng. 2023; 40:913–927. doi.org/10.1007/s43153-023-00317-y.
  15. Panichpakdee J, Larpkiattaworn S, Nuchchapong S, Naruepai B,Leekrajang M, Somwongsa P. Electrospinning of natural rubber latex-blended polyvinyl alcohol. Mater Today Proc. 2019; 17:2020–2027. doi.org/10.1016/j.matpr.2019.06.250.
  16. Cesar MB, BorgesFA, Bilck AP, Yamashita F, Paulino CG, Herculano RD. Development and Characterization of Natural Rubber Latex and Polylactic Acid Membranes for Biomedical Application. Journal of Polymers and the Environment. 2020; 28:220–230.2 doi.org/10.1007/s10924-019-01596-8.
  17. Thonte SS, Omprakash GB, Makanikar VG, Ovhal P, Sagar D. Smart Bioelectronics: The Future of Medicine is Electric. Int. J. of Eng. Tech. Science and Research. 2016; 3:3; 2394 – 3386.
  18. Akhtar N, Singh V, Yusuf M, Khan RA. Non-invasive drug delivery technology: development and current status of transdermal drug delivery devices, techniques and biomedical applications. Biomed Tech (Berl). 2020 May 26;65(3):243-272. doi: 10.1515/bmt-2019-0019. PMID: 31926064.
  19. Cabrera FC, Dognani G, Faita FL, dos Santos RJ, Agostini DLS, Bechtold IH, Crespilho FN, Job AE. J Mater Sci. 2016; 51:3003–3012. doi 10.1007/s10853-015-9611-y
  20. Chiu DT, de Mello AJ, Carlo DD, Doyle PS, HansenC, Maceiczyk RM, Wootton RCR. Small but Perfectly Formed? Successes, Challenges, and Opportunities for Microfluidics in the Chemical and Biological Sciences. Chem. 2017; 2:201–223. doi.org/10.1016/j.chempr.2017.01.009
  21. Urbina JCR, Osswald TA, GarciaJEE, Román AJ. Environmentally safe preservation and stabilization of natural rubber latex in an acidic environment. SPE Polymers. 2023; 1–12. doi: 10.1002/pls2.10089
  22. Roman AJ, DibisaO, PardoG, Rodríguez JC, Osswald TA. Evaluation of an ammonia-free natural rubber latex adhesive. SPE Polymers. 2023; 1–9. doi: 10.1002/pls2.10103.

Figures:

Similar Articles

  • Natural Rubber Latex on Medical Applications
    G Barrera Torres*, JC Rodriguez Urbina, Renivaldo Jose dos Santos, Flavio C Cabrera, Juan C Sánchez G and Jaime A Jaramillo Carvalho G Barrera Torres*, JC Rodriguez Urbina, Renivaldo Jose dos Santos, Flavio C Cabrera, Juan C Sánchez G, Jaime A Jaramillo Carvalho. Natural Rubber Latex on Medical Applications. . 2023 doi: 10.29328/journal.jcmhs.1001040; 4: 089-093

Recently Viewed

Read More

Most Viewed

Read More

Help ?