Assessing the Impact of Framework Agreements on the Availability of Essential Medicines: A Case Study of 65 Essential Medicines at the Upper East Regional Medical Stores, Ghana
Main Article Content
Abstract
Background: Access to Essential Medicines stands as a vital foundation to public health service delivery in any well-performing health system. In 2017, Ghana’s Ministry of Health established the Framework Agreement system, which selects prequalified suppliers to deliver 54 Essential Medicines (now 65 Essential Medicines) to Regional Medical Stores and Teaching Hospitals to address supply chain inefficiencies and maintain continuous availability.
Objectives: The study assessed the impact of these Framework Agreements on medicine availability at the Upper East Regional Medical Stores (UERMS), focusing on effectiveness, implementation challenges, and stakeholder perceptions.
Methods: A mixed-methods cross-sectional study design was employed. Quantitative data were collected through retrospective analysis of stock records from 2015 to 2024, comparing availability and lead times before and after implementation, while qualitative data were gathered through semi-structured interviews with key stakeholders.
Results: Quantitative data showed that before implementation, stock availability of these 65 Essential Medicines was 100%, with average lead times of 21–22 days. However, after implementation (2017–2024), medicine availability declined, and lead times increased by more than 40%, undermining the system’s objective of efficiency. Inconsistencies in supply were observed. Qualitative data showed that supplier performance faced system-level obstacles, including restricted emergency procurement flexibility, communication breakdowns between procurement entities and suppliers, and delayed payments, leading suppliers to lose commitment.
Conclusion: Framework Agreements demonstrate potential for better procurement transparency and cost-effectiveness, yet their existing implementation model negatively impacts medicine availability in the Upper East Region. The study recommends revision to allow emergency procurement, strengthen supplier performance monitoring, decentralise some procurement responsibilities, improve communication, and ensure timely payments.
Article Details
Copyright (c) 2026 Salia A, et al.

This work is licensed under a Creative Commons Attribution 4.0 International License.
World Health Organization. Ensuring essential medicine availability: global strategies and regional perspectives. Geneva: WHO Publications; 2023.
World Health Organization. WHO model list of essential medicines – 22nd list, 2021 [Internet]. Geneva: WHO; 2021 [cited 2026 Feb 23]. Available from: https://www.who.int/publications/i/item/WHO-MHP-HPS-EML-2021.02
Ghana Health Service. GHS annual holistic report [Internet]. Accra: Ghana Health Service; 2019 [cited 2026 Feb 23]. Available from: https://www.afro.who.int/sites/default/files/2020-10/Ghana%20Annual%20report%202019.pdf
Ghana Health Service. Holistic assessment report [Internet]. Accra: Ghana Health Service; 2020 [cited 2026 Feb 23]. Available from: https://www.moh.gov.gh/wp-content/uploads/2022/09/2020-Holistic-Assessment-Report_v8.3docx.pdf
Osei-Assibey A, Akweongo P. Assessment of availability of essential medicines in Sekondi-Takoradi Metropolis. J Biomed Pharm Res. 2017;6:100-111. Available from: https://www.semanticscholar.org/paper/Assessment-of-Availability-of-Essential-Medicines-Osei-Assibey-Akweongo/40a399b9ebc790328d2db7a3ed5d7c4796a5f070
Hogerzeil HV. Selection of essential drugs: standardised supply of essential drugs in Ghana—1. Trop Doct. 1986;16:113-116. Available from: https://doi.org/10.1177/004947558601600306
Hogerzeil HV. Essential medicines and human rights: what can they learn from each other? Bull World Health Organ. 2006;84:371-375. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC2627335/
Arney L, Yadav P, Miller R, Wilkerson T. Strategic contracting practices to improve procurement of health commodities. Glob Health Sci Pract. 2014;2:295-306. Available from: https://doi.org/10.9745/ghsp-d-14-00068
United Nations Office for Project Services. Framework agreements for health procurement: lessons from Africa [Internet]. Copenhagen: UNOPS; 2021 [cited 2026 Feb 23]. Available from: https://content.unops.org/publications/ASR/2021-ASR.pdf
European Medicines Agency. Framework agreements in pharmaceutical procurement: a strategic approach [Internet]. London: EMA Publications; 2020 [cited 2026 Feb 23]. Available from: https://www.ema.europa.eu/en/documents/other/eu-medicines-agencies-network-strategy-2020-working-together-improve-health_en.pdf
Ghana Ministry of Health. National pharmaceutical procurement guidelines. Accra: MoH Publications; 2022.
Bosu W, Aikins M, Sackey S. Challenges in pharmaceutical procurement in Ghana: a regional perspective. Ghana Med J. 2021;55(3):67-79.
Mensah K, Oppong R, Adjei F. Pharmaceutical supply chain bottlenecks in rural Ghana: the case of the Upper East Region. J Public Health Pharm. 2022;10(1):88-102.
Asante K, Osei D, Mensah J. Assessing the impact of procurement policies on medicine availability in Ghana. J Health Policy Syst Res. 2021;18(2):120-134.
Ghana Health Service. Annual report on essential medicines supply and distribution in Ghana [Internet]. Accra: GHS Publications; 2023 [cited 2026 Feb 23]. Available from: https://www.afro.who.int/sites/default/files/2024-06/WHO%20Ghana%202023%20Annual%20Report.pdf
Grindle MS. Policy content and context in implementation. In: Grindle MS, editor. Politics and policy implementation in the Third World. Princeton: Princeton University Press; 2017. p. 3-34. Available from: https://www.scirp.org/reference/referencespapers?referenceid=3557776
OECD. Health at a glance 2019: OECD indicators [Internet]. Paris: OECD Publishing; 2019 [cited 2026 Feb 23]. Available from: https://www.oecd.org/en/publications/health-at-a-glance-2019_4dd50c09-en.html