A HPV Vaccination beyond Cervical Cancer: Addressing the Rising Threat of Oropharyngeal Malignancies

Main Article Content

Mishaal Mustafa Ansari
Saman Adnan
Abeerah Aleem
Sabir Khan

Abstract


Purpose of review: The purpose of this letter is to highlight the rising incidence of malignancies associated with Human Papillomavirus (HPV) and how it is important to modify and implement public health policies to increase awareness and prevent the incidence rate of oropharyngeal cancer specifically in male.
Recent findings: Recent findings show a rising rate of HPV-related malignancies in the US and UK over the past two decades, particularly oropharyngeal cancers in men.
Summary: To summarize, the rising threat of HPV-associated oropharyngeal cancer emphasizes the urgent need for increased public health awareness and vaccination efforts specifically in males. Public health initiatives and further research are crucial for this growing issue.


Article Details

Ansari, M. M., Adnan, S., Aleem, A., & Khan, S. (2026). A HPV Vaccination beyond Cervical Cancer: Addressing the Rising Threat of Oropharyngeal Malignancies. Journal of Community Medicine and Health Solutions, 109–111. https://doi.org/10.29328/journal.jcmhs.1001084
Research Articles

Copyright (c) 2026 Ansari MM, et al.

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Wolf J, Kist LF, Pereira SB, Quessada MA, Petek H, Pille A, Maccari JG, Mutlaq MP, Nasi LA. Human papillomavirus infection: Epidemiology, biology, host interactions, cancer development, prevention, and therapeutics. Rev Med Virol. 2024 May;34(3):e2537. Available from: https://dx.doi.org/10.1002/rmv.2537

Filho AM, Warnakulasuriya S. Epidemiology of oral cancer in South and South-East Asia: Incidence and mortality. Oral Dis. 2024 Nov;30(8):4847-4854. Available from: https://dx.doi.org/10.1111/odi.14906.

Kim SI, Lee JW, Eun YG, Lee YC. A SEER-based analysis of trends in HPV-associated oropharyngeal squamous cell carcinoma. Infect Agent Cancer. 2024 Jun 28;19(1):29. Available from: https://dx.doi.org/10.1186/s13027-024-00592-5.

Chaturvedi AK, Engels EA, Pfeiffer RM, Hernandez BY, Xiao W, Kim E, et al. Human papillomavirus and rising oropharyngeal cancer incidence in the United States. J Clin Oncol. 2011 Nov 10;29(32):4294-301. Available from: https://dx.doi.org/10.1200/JCO.2011.36.4596.

Schache AG, Powell NG, Cuschieri KS, Robinson M, Leary S, Mehanna H, et al. HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology. Cancer Res. 2016 Nov 15;76(22):6598-6606. Available from: https://dx.doi.org/10.1158/0008-5472.CAN-16-0633.

Ferris RL, Westra W. Oropharyngeal Carcinoma with a Special Focus on HPV-Related Squamous Cell Carcinoma. Annu Rev Pathol. 2023 Jan 24;18:515-535. Available from: https://dx.doi.org/10.1146/annurev-pathmechdis-031521-041424

Spînu AD, Anghel RF, Marcu DR, Iorga DL, Cherciu A, Mischianu DLD. HPV vaccine for men: Where to? (Review). Exp Ther Med. 2021 Nov;22(5):1266. Available from: https://dx.doi.org/10.3892/etm.2021.10701.

Rosado C, Fernandes ÂR, Rodrigues AG, Lisboa C. Impact of Human Papillomavirus Vaccination on Male Disease: A Systematic Review. Vaccines (Basel). 2023 Jun 9;11(6):1083. Available from: https://dx.doi.org/10.3390/vaccines11061083.

Kusters JMA, Obels I, van der Klis FRM, King AJ, Heijman T, Heijne JCM, et al. Prevalence and risk factors for HPV seropositivity and anogenital DNA positivity among men who have sex with men: a repeated cross-sectional study. Int J Infect Dis. 2024 Aug;145:107094. Available from: https://dx.doi.org/10.1016/j.ijid.2024.107094.

Zhaffal A, Salame L. Semen human papillomavirus (HPV) shedding in males: frequency, clinical significance, and reproductive outcomes—literature review. Egypt J Med Hum Genet. 2023;24:74. Available from: https://dx.doi.org/10.1186/s43043-023-00131-z

CDC. Cancer. 2024 [cited 2025 Oct 21]. HPV and Oropharyngeal Cancer. Available from: https://www.cdc.gov/cancer/hpv/oropharyngeal-cancer.html

Chenafi-Adham S, Boussetta-Charfi O, Pillet S, Bourlet T. Impact of Human Papillomavirus (HPV) on Male and Female Fertility. Pathogens. 2024 Dec 7;13(12):1076. Available from: https://dx.doi.org/10.3390/pathogens13121076.

Macilwraith P, Malsem E, Dushyanthen S. The effectiveness of HPV vaccination on the incidence of oropharyngeal cancers in men: a review. Infect Agent Cancer. 2023 Apr 24;18(1):24.

Human papillomavirus vaccines: WHO position paper, December 2022 [Internet]. [cited 2025 Oct 21]. Available from: https://www.who.int/publications/i/item/who-wer9750-645-672

Thilly N, Michel M, Simon M, Bocquier A, Gagneux-Brunon A, Gauchet A, et al. Effectiveness of a School- and Primary Care–Based HPV Vaccination Intervention: The PrevHPV Cluster Randomized Trial. JAMA Netw Open. 2024 May 23;7(5):e2411938.

Mavundza EJ, Iwu-Jaja CJ, Wiyeh AB, Gausi B, Abdullahi LH, Halle-Ekane G, et al. A Systematic Review of Interventions to Improve HPV Vaccination Coverage. Vaccines. 2021 June 23;9(7):687.